This review discusses the effects of hormone replacement therapy (HRT) on the heart health of trans people. It found that hormone therapy in trans people may increase risk for blood clots and high cholesterol, with conflicting findings on effects on blood pressure. The review emphasizes the need for further studies.
“In studies that followed trans people on hormone therapy, the rates of myocardial infarction and stroke were consistently higher in trans women than trans men. There is strong evidence that estrogen therapy for trans women increases their risk for venous thromboembolism over 5 fold.”